结论酒石酸美托洛尔片单剂量和多剂量给药后，安全性良好。

Conclusion There are good safety after administrating single and multiple oral dose of metoprolol tartrate.

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目的建立单室模型药物血管外多剂量给药的吸收和清除药动学的残数法计算方法。

Objective To establish a feathering method for processing the pharmacokinetic parameters of mono-compartment drugs administered by non-parenteral route by repeated doses.

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目的：建立一种简便的多剂量二室模型静脉推注给药的给药方案设计方法。

AIM: To establish a calculation of dosage regimen design on multiple dosing intravenous bolus injection administration of two compartment model.

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