全基因组学关联研究所产生的数据结果是巨大的，但是很少能直接鉴别出突变和病症之间的功能关系。

The output of genome-wide association studies is vast, yet it is rarely straightforward to identify the functional connection between a variant and a disorder.

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目前报道的生物素酶基因突变超过80余种，全羧化酶合成酶基因突变20多种。

Thus far more than 80 mutations in the gene of biotinidase and more than 20 mutations in the holocarboxylase synthetase gene have been reported.

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