目的了解拉米夫定耐药与HBV基因型及HBV基本核心启动子(BCP)突变之间的关系。

Objective To investigate the relationship of HBV Lumivudine resistant and HBV genotypes and basic core promoter (BCP) mutation.

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与野生基因型携带者相比较，突变杂合和突变纯合基因型携带者的子代罹患CHD的OR值为0.46 (95% CI： 0.31 ~ 0.69)。

Compared with wild type genotype, offsprings of mutant heterozygote and homozygote were at higher risk of CHD, with OR0.46 (95%ci: 0.31 ~ 0.69).

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紧密连接蛋白克劳丁-1单克隆抗体能够有效地抑制大多数基因型丙型肝炎病毒感染和自患者分离的高度突变的丙型肝炎病毒准种感染。

The monoclonal antibodies against CLDN1 efficiently inhibited infection by HCV of all major genotypes as well as highly variable HCV quasispecies isolated from individual patients.

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