由单个基因发生突变引起的遗传病。

Single-gene disorder --- A disorder due to one or a pair of mutant alleles at a single locus.

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图位克隆表明一个编码SPP的基因发生突变。

The mutated gene was cloned by map-based cloning, and was shown to encode an SPP.

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如同其它癌症，卵巢癌细胞中的基因发生突变，结果产生了能够改变正常信号转导功能的蛋白。

Genes that are mutated in ovarian cancer, as in other cancers, result in the production of proteins that alter the normal function of signaling pathways in cells.

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And one bit of evidence that these genes are implicated is that some unfortunate people have point mutations in these genes.

证明这些基因起作用的一些证据,是这些基因会在某些不幸的人身上,发生点突变

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