该方法把虚拟测量处理为等式约束，避免了由于权因子分散而导致的数值病态问题。

In the proposed method, virtual measurements are treated as equality constraints, which avoids the numerical ill-conditioning problem due to the disparity in weighting factors.

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复制的起源分散在整个基因组中，其活性主要通过前复制因子和复制因子的连续结合来调控。

Origins of replication are dispersed throughout the genome, and their activities are regulated via the sequential binding of pre-replication and replication factors.

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复制的起源分散在整个基因组中，其活性主要通过前复制因子和复制因子的连续结合来调控。

Origins of replication are dispersed throughout the genome, and their activities are regulated via the sequential binding of prereplication and replication factors.

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