吗啡通过作用于神经突触来缓解疼痛,但它同时也兴奋了胶质细胞,可能也加剧了该药的副作用,如嗜睡,耐受,疼痛加剧和成瘾。
Morphine deadens pain by acting at nerve synapses, but it also activates glial cells, possibly worsening the drug's side effects, such as drowsiness, tolerance, worsening of pain, and addiction.
观察并探讨硬脂酸纳米吗啡(SLN-M)单次注入大鼠硬膜外腔后的镇痛效应及用药后的药代动力学特点。
To observe the analgesic effect and lumbar cerebrospinal fluid and serum kinetics of single dose solid lipid nanoparticles morphine(SLN-M) after epidural administration in rats.
目的:探讨吗啡作为第三阶梯止痛药对晚期癌症患者重度疼痛治疗的效果、剂量滴定及不良反应。
Objective: To approach the clinical effect, titration dosages and side effect of oral morphine as the third analgesics ladder for the advanced cancer patients with severe pain.
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