厄罗替尼对肺腺癌细胞凋亡的影响-临床医学论文-论文联盟 关键词】 厄罗替尼;EGFR;A549细胞;细胞凋亡 [gap=932]Key words】 Erlotinib;EGFR;A549 cell;Cell apoptosis
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厄罗替尼盐酸盐 Erlotininb hydrochloride
Objective: Gefitinib and Eelotinib are sort of selectivity inhibitor of epidermal growth factor receptors(EGFR)tyrosine kinase, ,and are used in treating advanced non-small cell lung cancer(. NSCLC)。
目的:吉非替尼与厄罗替尼是一种表皮生长因子受体酪氨酸激酶的选择性抑制剂,临床常用于治疗晚期非小细胞肺癌,本文回顾性分析了吉非替尼与厄罗替尼治疗晚期(ⅢB/Ⅳ期)非小细胞肺癌的疗效、不良反应及两药疗效和副反应对比。
参考来源 - 吉非替尼与厄罗替尼治疗晚期非小细胞肺癌的临床分析·2,447,543篇论文数据，部分数据来源于NoteExpress
厄罗替尼布联合卡培他滨同样用于一线药物吉西他滨治疗失败的患者。
Erlotinib is also being evaluated in combination with capecitabine in patients who failed first-line therapy with gemcitabine.
应用厄罗替尼布和安慰剂组都有11(8%)名患者出现3级或更高的AST升高。
Grade 3 or greater elevations of AST were reported in 11 and 8% of patients receiving erlotinib and placebo, respectively.
联合应用靶向因子如egfr阻滞剂-如厄罗替尼布和环氧化酶2抑制因子(塞来考昔)-还需要临床验证。
Also the combination of different target agents, such as combining the EGFR blockers - such as erlotinib and the cyclooxygenase-2 inhibitor (celecoxib) - needs to be investigated in clinical trials.
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