关键词：注射用法罗培南钠；单次给药；多次给药；耐受性试验 [gap=1431]Key words：faropenem sodium for injection；single-dose；multiple·dose；tolerability trial
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通过提高单次给药剂量 dose escalation
Object: To comment on the analgesic effect and the safety of NSAID Lornoxicam during the 48 hrs after a single dose applied in laparoscopic cholecystectomy under general anesthesia with laryngeal mask airway.
目的:评价非甾体抗炎药氯诺昔康用于喉罩全麻下腹腔镜胆囊切除术中单次给药后48小时的镇痛疗效及安全性。
参考来源 - 氯诺昔康在喉罩全麻下腹腔镜胆囊切除术中的应用Clinical tolerance was assessed within 84 days for single-dose group.
单次给药耐受性试验观察至84 d。
参考来源 - 注射用重组人CTLA4·2,447,543篇论文数据，部分数据来源于NoteExpress
方法：单次给药后检测肝脏系数和血液生化指标，观察组织病理学变化。
METHODS: Changes of liver coefficient, serum biochemistry, and histopathology were detected after single dose.
无论是各周血糖水平的变化，还是单次给药实验、糖耐量实验，仙人掌粗多糖都有明显的降血糖作用。
Blood glucose levels were determined every week, the effect of single administration was monitored in the first week, and glucose tolerance was determined after three weeks.
减量重复给药后发现，随着第二次给药剂量减少，脑组织中药物浓度与血清药物浓度的比值下降至0.7，近似可接近单次给药后的比值。
In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.
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