在正常生长条件下，热激因子处于钝化的单体状态，而当热激时，热激因子形成三聚体并与DNA结合，同时通过转录激活域的活化而激活热激基因的表达。
HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization, high affinity binding to DNA and transcriptional activity.
但是即使用了单体，管理状态也是困难的——所以不要尝试这样做。
But even with monads, managing state is difficult — so don't try.
正如我在前面提到过的，单体可以表示状态的变化。
As I mentioned earlier, monads can represent changes in state.
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