他补充说，挑战在于这一相关性研究的下一步，即弄清楚这些变异基因如何可能导致分子老化过程的功能性变化。

He added that the challenge was to next move beyond this correlative study to figure out how these gene variations may lead to functional changes that contribute to the molecular process of aging.

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这种变化的动机是根据报告实现改善的功能性。

The motivation for change was to achieve improved functionality with respect to reporting.

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首先，确保发生任何非功能性的变化之前，已经存在已知的、良好的、签署过的功能基线。

First, it ensures that you have a baseline of known-good, signed-off functionality before making any non-functional changes.

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