可变剪接在发育、分化和癌症等过程中发挥着非常重要的作用。
Alternative splicing plays an important role in processes such as development, differentiation and cancer.
本研究中，我们评估了SF3b剪接复合体的关键部分SF3B1和SF3B3在ER阳性内分泌耐药乳腺癌中的作用。
In this study, we evaluated the role of SF3B1 and SF3B3, critical parts of the SF3b splicing complex, in ER-positive endocrine resistance.
我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
We demonstrated a direct role for histone modifications in alternative splicing.
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