设计：前瞻性随机研究。
其稀少性使得对该损伤实施前瞻性随机研究变得非常困难。
Their rarity makes it extremely difficult to study these injuries in a prospective or randomized manner.
一些前瞻性随机研究也表明延长治疗对于起始免疫应答缓慢的患者有益。
There are a number of randomized prospective studies that suggest that extending therapy for slow initial responders may be effective.
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