前药,也称前体药物、药物前体、前驱药物等,是指药物经过化学结构修饰后得到的在体外无活性或活性较小、在体内经酶或非酶的转化释放出活性药物而发挥药效的化合物。1958年,Albert在英国自然杂志上发表文章提出了前体药物的概念。目前已经在神经系统药物,抗肿瘤系统药物和抗病毒药物有着很大的作用。
前体药物的合成 Synthesis of prodrugs
前体药物制剂 pro-drug preparations
前体药物疗法 Antibody directed enzyme prodrug therapy ; ADEPT
前体药物治疗 GDEPT ; VDEPT ; virus-directed enzyme/prodrug therapy
前体药物的分解 Synthesis of prodrugs
生物前体药物 bioprecursors prodrugs
酶前体药物治疗 Antibody-directed enzyme prodrug therapy ; ADEPT
酶前体药物疗法 gene directed enzyme prodrug therapy
酶一前体药物疗法 antibody-directed enzyme prodrug therapy ; ADEPT
Conclusion: Pyritinol tetrapropionate ester prodrug is a promising prodrug.
结论:吡硫醇丙酯是具有良好前景的前体药物。
参考来源 - 吡硫醇丙酯前体药物的合成及其降解动力学·2,447,543篇论文数据,部分数据来源于NoteExpress
本文对抗病毒前体药物研究进展作介绍。
The research progress in the prodrugs of antiviral drugs are reviewed.
随着病程进展,病人细胞转化前体药物的能力也越来越弱。
The further the disease progresses, the weaker the capacity of the patient's cells to convert the precursor drug.
方法通过丁二酸酐搭桥,合成地塞米松葡聚糖酯前体药物;
METHODS Dexamethasone succinate dextran was synthesized in an anhydrous environment.
应用推荐