最有效的方法是简单的做一个计划，并允许其有瑕疵，在行动中设置计划，然后适应、调整或者根据世界变化更换计划。
The more effective approach is to simply pick a plan with the knowledge that it's flawed, set the plan in action, and then adapt, revise, or switch plans as the world unfolds.
基因药物就是一个强有力的新工具，其目标指向有瑕疵的基因或导致各种癌症的基因路径。
One powerful new tool is genomic medicine, which targets faulty genes or their pathways responsible for various kinds of cancers.
当然，即使是美玉也难免有瑕疵，赢得全球赞誉的宫崎骏动画也有其局限之处。
Certainly, it's hard to avoid flaw even for jade, and Hayao Miyazaki's animations that gained recognitions all over the world also have their localization.
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