依赖性蛋白激酶抑制剂 cyclin-dependent kinase inhibitor ; CDKI
目的探讨翼状胬肉组织中细胞周期蛋白依赖性激酶抑制剂P16的表达，了解其在翼状胬肉发病机制中的作用。
Objective To observe the expression of cyclin kinase inhibitor P16 in pterygium and to investigate its effects on the pathogenesis of pterygium.
结论翼状胬肉中细胞周期蛋白依赖性激酶抑制剂p16的低表达可能导致翼状胬肉细胞周期紊乱，其增殖失去控制。
Conclusion The lower expression of cell circle related kinase inhibitor in pterygium may play an important role on proliferation and pathogenesis of pterygium.
方法：应用SP免疫组化法，检测P 21, P 27等细胞周期依赖性激酶抑制剂和增殖细胞核抗原(pcna)在角膜上皮不同部位的表达情况。
METHODS: the expressions of CKI, P27, P21 and proliferating cell nuclear antigen (PCNA) were tested in different regions of corneal epithelium by SP immunohistochemistry.
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