他尽了最大的努力去搬动它，但那箱子一点也不动。
He tried his best to move it, but the box would not move at all.
他尽了最大的努力，但他是一只肥胖的动物，腿也短，而他们仍然逼近。
He did his best, but he was a fat animal, and his legs were short, and still they gained.
尽管他尽了最大的努力，他最终还是没有得到奎宁（一种治疗疟疾的药物）。
Despite his best efforts, however, he did not end up with quinine.
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