本文综述了谷胱甘肽及其相关酶系统在肿瘤多药耐药中的作用，介导多药耐药的可能机制以及谷胱甘肽类似物结构与转运活性的关系。
We introduced the effects on MDR, the possible mechanisms of glutathione and related enzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper.
结论P -糖蛋白介导的多药耐药是膀胱癌腔内灌注化疗失败、肿瘤复发的重要原因。
Conclusion the P-glycoprotein-mediated MDR may be an important cause of recurrent of bladder cancer after treated by perfusion chemotherapy.
应用推荐