本提议计画是在使用新的核磁共振技术来 研讨 二氢叶酸还原 ( Dihydrofolate reductase )与抑制 剂的相互作用(Interaction),进而了解其结构与功 能上之关系.
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二氢叶酸还原酶 [生化] dihydrofolate reductase ; DHFR ; dihydrofolic acid reductase ; beta-Triphosphopyridine Nucleotide Tetrasodium Salt
二氢叶酸还原酶基因 DHFR ; dihydrofolate reductase
二氢叶酸还原酶抗体 Anti-DHFR
二氢叶酸还原酶缺乏症 dihydrofolate reductase deficiency
如二氢叶酸还原酶基因 dihydrofolate reductase
人二氢叶酸还原酶 human dihydrofolate reductase
二氢叶酸还原酶抑制剂 Dihydrofolate reductase inhibitor
该方法已用于设计抑制剂大肠杆菌二氢叶酸还原酶和人类磷脂酶a2。
This method has been applied to the design of inhibitors for E. coli dihydrofolate reductase and human phospholipase A2.
建立了一种采用毛细管电泳法(CE)测定二氢叶酸还原酶(DHFR)反应动力学参数的新方法。
A novel screening method for dihydrofolate reductase inhibitors (DHFRI) using high performance capillary electrophoresis (HPCE) was developed.
抗叶酸类抗疟药的抗药性机制已基本搞清，与其作用靶酶二氢叶酸还原酶或二氢蝶酸合成酶基因点突变相关。
The molecular mechanism of resistance to the antifolates has been well characterisied and is due to structural changes in the target enzymes resulting from the point mutations of DHFR or DHPS gene.
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