结论体外定点突变系统可以对基因进行精细的修饰，为建立更精确地模拟人类疾病的动物模型打下基础。

Conclusion the site specific point mutation system can modify human gene in vitro more accurately. It is useful in the setting up of animal models.

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我们以糖修饰酞菁作为近红外荧光探针，以肝癌肿瘤鼠为动物模型，通过活体荧光成像研究探针在各脏器的聚集、分布以及成像效果。

Mice with liver cancer were used as animal model and assessed by in vivo fluorescence imaging to evaluate near-infrared imaging effect and organ aggregation and distribution of probe in vivo.

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