已有研究表明丙型肝炎病毒进入细胞内需要紧密连接蛋白克劳丁-1（CLDN1）。
The tight junction protein claudin-1 (CLDN1) has been shown to be required for entry of HCV into the cell.
目的：构建丙型肝炎病毒(HCV)全长及3种不同缺失突变的核心蛋白基因的原核表达载体，并在大肠杆菌中表达。
AIM: to construct the recombinant plasmids expressing full-length HCV core protein gene and 3 different deletion mutated hepatitis core protein genes and to express them in E. coli.
紧密连接蛋白克劳丁-1单克隆抗体能够有效地抑制大多数基因型丙型肝炎病毒感染和自患者分离的高度突变的丙型肝炎病毒准种感染。
The monoclonal antibodies against CLDN1 efficiently inhibited infection by HCV of all major genotypes as well as highly variable HCV quasispecies isolated from individual patients.
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