依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).
近年来的研究表明，血管内皮生长因子、基质金属蛋白酶- 2和基质金属蛋白酶- 8在动脉粥样硬化斑块不稳定中起着重要作用。
Recent studies have suggested that vascular endothelial growth factor, matrix metalloproteinase-2 and-8 play important roles in the instability of atherosclerotic plaques.
但在不稳定性心绞痛患者中，基质金属蛋白酶的水平与CD 40l的相关性以及与不稳定性心绞痛患者的危险度分层、发生心脏事件的预测价值方面尚缺乏进一步的探索。
But it is short of further exploration in the correlation between matrix metalloproteinase and CD40L or risk stratification and predicting the value of heart incidence in unstable angina.
应用推荐