significant problem

• 1. 重大问题: major issues | a major problem | vital problem | major question
• 2. 关系全局的重大问题: major issues of overall significance | issues of underlying importance/of overriding importance
• 3. 经济社会发展重大问题: major issues relating to economic and social development

更多释义

• 1.我认为重大问题必须找我商量。
  I expect to be consulted about major issues.
  dict.yoduao.com
• 2.他们模仿长辈的口气讨论重大问题。
  They discussed important issues in imitation of their elders.
  dict.yoduao.com
• 3.不过，确实出现了一个重大问题。
  One major problem did present itself, though.
  dict.yoduao.com

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