1.  big problem
2.  big issue
3.  large problem

• 1. 大问题: BIG ISSUE | big question | The Big Questions | large problem
• 2. 关系全局的重大问题: major issues of overall significance | issues of underlying importance/of overriding importance
• 3. 经济社会发展重大问题: major issues relating to economic and social development

更多释义

• 1.我们预料不会发生什么大问题。
  We don't anticipate any major problems.
  dict.yoduao.com
• 2.有两大问题困扰有听觉障碍的人。
  There are two main problems which afflict people with hearing impairments.
  dict.yoduao.com
• 3.我们遇上了大问题。
  We have encountered major problems.
  dict.yoduao.com

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