• 1. clockwise PK-PD model: 短时程速效模式
• 2. counter clockwise PK-PD model: 滞缓慢效模式
• 3. effect-compartment PK-PD model: 药动学与药效学结合模型

• 1.Objective To determine the PK/PD parameters which is more dependent on the inhibition of resistant mutants using vitro pharmacodynamic model.
  目的通过体外药效学模型探讨预测抑制细菌耐药突变的PK/PD参数折点。
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