• 1. five major problems: 五大难题
• 2. five major difficult problems: 五大难题

• 1.The problems were particularly acute in the company's top ten major metro sales markets, where it had been five years since the company had received local media support.
  在该公司的十大城市销售市场上，问题尤其严重，因为当地的新闻媒体已经五年没有为该公司做宣传了。
  dict.yoduao.com
• 2.There are five parts in this thesis: first, analyzing the current evaluation status of business performance of Chinese companies and pointing out the major existing problems;
  第一部分对我国企业经营业绩评价现状进行了分析，指出其中存在的主要问题；
  dict.yoduao.com

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