目的：比较文拉法辛与马普替林治疗抑郁症的疗效及安全性。
Objective: To compare the clinical efficacy and safety of venlafaxine with maprotiline in the treatment of depression.
目的探讨抑郁症患者吸烟对马普替林治疗剂量、疗效和不良反应的影响。
Objective To study the influence between smoking and therapeutic dosage, side effects of maprotiline in depressive patients.
结论：氟西汀联用马普替林对抑郁伴发焦虑症状与文拉法辛疗效相当，不良反应相似。
CONCLUSION: Fluoxetine combined with maprotiline in the treatment of depression associated with anxiety, as venlafaxine, show equivalent clinical effects with similar adverse reactions.
方法采用随机对照方法，以马普替林为对照组，应用HAMD、HAMA、TESS量表，在疗前、疗后1、2、4、6周进行疗效及副反应评定。
Methods the patients were randomly assigned into venlafaxine and maprotiline group and tested with HAMD, HAMA and TESS at the time of weeks 1, 2, 4, 6 weeks after treatment.
方法采用随机对照方法，以马普替林为对照组，应用HAMD、HAMA、TESS量表，在疗前、疗后1、2、4、6周进行疗效及副反应评定。
Methods the patients were randomly assigned into venlafaxine and maprotiline group and tested with HAMD, HAMA and TESS at the time of weeks 1, 2, 4, 6 weeks after treatment.
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