鼻腔给药具有吸收迅速、避免首过代谢等优点，在近年来已引起广泛关注。
Drug delivery through the nasal route has received a lot of attention recently because of its advantages such as rapid absorption, avoidance of first-pass elimination and so on.
目的：探讨小肠在首过效应中的作用。
Objective: To explore the first-pass effect in Small intestine.
结论染料木黄酮首过代谢突出，血浆中药物主要以葡糖醛酸结合形式存在。
Conclusion Due to significant first pass metabolism, the drug was mainly existed in the form of glucuronidated genistein in the plasma.
结论DBDCT在大鼠肝微粒体中代谢较快，提示该药可能肝首过效应较强。
ConclusionThe metabolism of DBDCT in rat liver microsomes was faster, suggesting that the liver first-pass effect of the drug may be stronger.
目的：采用MR快速序列研究猪急性心肌梗死的首过灌注和延迟时相影像特点。
Objective: To study myocardial first -pass perfusion and delayed- enhancement features in acute myocardial infarction by using fast MRI scanning sequence.
目的采用MR首过灌注成像评价急性心肌梗死心肌组织血流灌注特点及治疗效果。
Objective To evaluate the characteristics of myocardial perfusion and therapeutic effect of acute myocardial infarction using first pass perfusion MR imaging.
目的评价心肌首过灌注磁共振成像技术对肥厚型心肌病(HCM)心肌缺血的诊断作用。
Objective To access the diagnostic value of magnetic resonance first pass perfusion imaging in hypertrophic cardiomyopathy (HCM) with myocardial ischemia.
文献表明槲皮素生物活性低是由于其低的生物利用度，溶解性差与首过效应是影响其生物利用度的主要因素。
Documents show that the low biological activity of quercetin is due to its low bioavailability. Poor solubility and first-pass effect are the main factors that affect its bioavailability.
结果药物的溶解性、稳定性、膜通透性和首过作用等生物药剂学性质是影响药物口服后经胃肠道吸收的主要因素。
Results The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
功能注释高度依赖于与其他已知基因或蛋白质的序列相似性，因为在一个基因组规模上的大多数最初的“首过”功能注释是可传递的。
Functional annotation is highly dependent on sequence similarity to other known genes or proteins as the majority of initial "first-pass" functional annotation on a genomic scale is transitive.
他其中创作的一首较长的诗歌在《班格达森》（音译——译注）上发表后，获得非常好的评价，我听到过这首歌被许多人演唱过，而演唱这些歌的人对词的作者却一无所知。
One of his longer poetic pieces was much appreciated when it appeared in the Bangadarsan, and I have heard his songs sung by many who knew nothing at all about their composer.
尽管如此，《哈罗德•品特颂》仍是一首激动人心的颂歌，献给一个勇敢生活的人以及他所遗留下的珍贵作品，其中一些作品曾被忽视过。
Still, “A Celebration of Harold Pinter” is a stirring tribute to a man who lived boldly, and the trove of work—some of it overlooked—that he left behind.
它于1914年首次以大幅删减过的版本发行。
It was first published in 1914 in a highly expurgated version.
G20首脑上个月拥护过这个想法，但他们真正的意愿是不是朝着这个方向，还很难确定。
And it is far from clear that this is what the G20 leaders intended when they endorsed the idea last month.
三年之后，研究组组长格雷戈里·伯恩斯在观赏著名音乐电视节目《美国偶像》的一段情节时意识到其中一首歌曲在他当年的研究中出现过。
Three years later, lead researcher Gregory Berns was watching an episode of the popular music show American Idol and recognized one of the songs that had featured in his study.
他是星期六首先抵达拉法边境站的几百人中之一，之后他搭上接驳车，接驳车将他载过边境大门进入埃及。
He is among the first of hundreds who arrived at the Rafah border terminal Saturday before boarding a shuttle bus that would take him past a gate into Egypt.
她曾经唱过一首有美妙旋律的歌。
许多人，或许是大多数人，曾经历过一听到某首特别的乐曲而突然迸发情感；
Many, perhaps most, people have experienced a sudden rush of emotion on hearing a particular piece of music;
考古学家们说这些墓穴是为了嘉奖一位首席牙医和另外两名服侍过古埃及法老及家眷的牙医。
Archaeologists say the tombs were meant to honor a chief dentist and two others who treated ancient Egypt's pharaohs and their families.
就像我以前说过的，我不想写一首沮丧的颂歌，只是想像雄鸡一样在早晨激情地歌唱，站在自己的栖木上，仅仅是为了把邻人唤醒。
As I have said, I do not propose to write an ode to dejection, but to brag as lustily as chanticleer in the morning, standing on his roost, if only to wake my neighbors up.
本研究利用边界元法求解了悬板分层式引水渠首的悬板区过流问题。
Boundary element method to calculate the free surface flow over the plate region of the hanged-plate two storied intake work is presented in this paper.
著名的普利策奖星期一首次向一篇从未在报纸媒体发表过的文章颁发了一个奖项。
A prestigious Pulitzer Prize was awarded for the first time Monday to a story that never was published in print.
她小时候曾经告诉过我：“你刚做的表情好像妈妈。”还有一次，我为她唱一首母亲曾唱过的歌，她哭了。
As a child, she once told me, "You made a face like Mama just now," and another time, she cried when I sang her a song our mother used to sing.
秋雨淋浴过的地方，到处清晰地刻印下一首首汗水与心血换来的丰收诗篇！
Autumn rain showers over the place, everywhere, under a clear engraving one song after another in exchange for the sweat and hard work of harvest poem!
秋雨淋浴过的地方，到处清晰地刻印下一首首汗水与心血换来的丰收诗篇！
Autumn rain showers over the place, everywhere, under a clear engraving one song after another in exchange for the sweat and hard work of harvest poem!
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