目的研究阿片受体拮抗剂纳洛酮对大鼠脑震荡后空间学习记忆缺失的影响。
Objective to investigate the effects of naloxone a competitive opioid receptor antagonist on spatial learning and memory deficits following concussive brain injury in rats.
目的研究阿片受体拮抗剂纳洛酮对大鼠脑震荡后空间学习记忆缺失的影响。
Objective to investigate the effects of naloxone, a competitive opioid receptor antagonist, on spatial learning and memory deficits following concussive brain injury in rats.
背景：隔-海马区的胆碱能神经通路是空间学习记忆的重要部位，此区神经元中又富含阿片受体。
BACKGROUND: the pathway of cholinergic nerve also with rich opium receptor in the septum-hippocampus areas is an important part for spatial learning memory.
纳洛酮为一特异性阿片受体阻滞剂，广泛用于麻醉剂过量、休克、酒精中毒、脑梗死等方面的治疗。
Naloxone is a narcotic antagonist that prevents or reverses the effects of opioids. It is widely used in the treatment of narcotics and alcohol intoxication, shock, cerebral infarct.
贝洛克说，这些结果很有趣，因为我们看到随着脑部阿片受体基因的改变，它控制着我们一顿饭吃多少。
"These results are interesting because we saw changes in opioid receptor gene expression in a brain area that controls how much we eat during a meal", said Bello.
脑啡肽是机体产生的一种类型的缓解疼痛感觉的阿片受体，但在慢性疼痛的情况下，这些物质似乎流量不够。
Enkephalins are a type of opiate that the body produces to dull pain sensations, but in cases of chronic pain, these agents appear not to flow in sufficient quantities.
阿片类镇痛剂的临床应用具有悠久的历史。然而，阿片受体的功能，特别是其在脑内的作用，尚未完全阐明。
The use of opioid analgesics has a long history in clinical Settings, although the functions of opioid receptors, especially their role in the brain, are not well understood yet.
结论：褪黑色素可通过作用于外侧缰核的阿片受体而影响其痛相关神经元对痛刺激的反应，这可能是褪黑色素中枢镇痛机制之一。
Conclusion: Melatonin can change the responses of pain neurons to pain stimulation via opioid receptor in the LHb, which might be one of analgesic mechanisms by MEL.
纳曲酮(ntx)是一个阿片受体的拮抗剂，因为他缺乏内在的活性，所以会导致细胞内的阿片类分子和阿片受体补偿性的增加。
Naltrexone (NTX) is a general opioid receptor antagonist devoid of intrinsic activity that results in a compensatory elevation in endogenous opioids and opioid receptors.
为了测试YQRFSR是否是通过对身体本身的阿片起作用，研究者对其它的动物注射一种能接合本身阿片受体导致痉挛的化合物。
To test whether YQRFSR worked via the body's natural opiate pathway, the team injected other animals with a compound known to cause spasms by tickling natural opiate receptors.
“在胚胎发育过程中，阿片类镇痛药物及其受体会起到生长调节素的作用，这或许可以解释我们的研究发现”，该研究报告著者CherylS. Broussard说道。
“Opioids and their receptors act as growth regulators during embryologic development, which may explain our findings, ” said Cheryl S. Broussard, the paper’s lead author.
受体亲和力决定了占据一定百分比的受体所需阿片类药物的量，而内在活性决定了阿片类药物的镇痛效果。
While receptor affinity determines the amount of opioid needed to occupy a given percentage of receptors, it is the intrinsic activity of the opioid that determines its analgesic efficacy.
贝洛克博士和他的同事们报告说，无论不停吃东西还是大量食用高脂肪食物，高糖饮食都会在控制食物摄入的大脑区域改变阿片类受体量。
Dr. Bello and colleagues report that either continuous eating or binge eating a high fat, high sugar diet alters opioid receptor levels in an area of the brain that controls food intake.
贝洛克博士和他的同事们报告说，无论不停吃东西还是大量食用高脂肪食物，高糖饮食都会在控制食物摄入的大脑区域改变阿片类受体量。
Dr. Bello and colleagues report that either continuous eating or binge eating a high fat, high sugar diet alters opioid receptor levels in an area of the brain that controls food intake.
应用推荐