目的研究压力超负荷时心肌闰盘的变化。
Objective To investigate the change of intercalated discs induced by pressure overload.
出生后，结蛋白表达主要集中于明带Z线和闰盘。
After birth, desmin expression was mainly concentrated in the Z lines of I bands and intercalated disks.
在细胞表面、胞浆中及闰盘处出现棕黄色颗粒为阳性细胞。
The positive cells displayed brownish yellow granules on the surface, cytoplasm and intercalated disc.
本实验对大鼠心房心肌细胞的肌浆网与闰盘间的关系进行了超微结构观察。
The ultrastructure of the relationship between the sarcoplasmic (SR) and the intercalated disk in the atrial myocardial cells of the heart is studied.
光镜下见大量移植的单个核细胞生长，移植细胞间及与宿主细胞间均有闰盘连结。
Light microscopy revealed the presences of engrafted MBMC and the presence of nascent intercalated disks connecting the engrafted cell and the host myocardium.
结果术后10周手术组心肌闰盘的粘着膜、桥粒、间隙连接结构模糊，连接间隙增宽；
Results At the 10th week after constriction, the structure of cadherin, desmosome and gap junction in intercalated discs were destroyed, gap of intercellular space widened.
结果：正常小鼠心肌中未见穿孔素阳性表达，连接蛋白43在心肌闰盘中呈阳性表达。
Results in normal mice, perforin was negative and connexin 43 was located in the intercalated disks of cardiac muscle.
结论：骨髓间质干细胞分化为心肌细胞过程中，随培养时间延长及细胞密度增加逐渐形成闰盘样结构。
CONCLUSION: During the process of BMMSCs differentiating into cardiomyocytes, intercalated disc-like structure is gradually formed with increase in culture time and cell density.
结论：骨髓间质干细胞分化为心肌细胞过程中，随培养时间延长及细胞密度增加逐渐形成闰盘样结构。
CONCLUSION: During the process of BMMSCs differentiating into cardiomyocytes, intercalated disc-like structure is gradually formed with increase in culture time and cell density.
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