另人吃惊的是，这个因子证明是具有一般转录抑制因子nc2的明显的特征。
Surprisingly, the factor turns out to have been previously characterized as a general repressor of transcription, NC2, an observation explained by its ability to repress TATA-box-containing promoters.
PML是一个生长和转录抑制因子，研究表明PML表达变化可能和一些实体癌的发生有关。
PML is a growth and transformation suppressor, and it may play a role in the oncogenesis of solid tumors.
一个独特的转录因子网络可能赋予其自我更新，同时抑制分化。
A unique network of transcription factors might characterize self-renewal and simultaneously suppress differentiation.
具体地，本发明显示E2-EPF5活性的抑制降低VEGF以及其他在低氧应答中由转录因子HIF-1调节的蛋白质的产生。
In particular, inhibition of E2-EPF5 activity is shown to reduce the production VEGF, as well as other proteins regulated the transcription factor HIF-1, in response to hypoxia.
本研究表明，干扰素可以通过抑制肿瘤依赖性转录因子的表达来达到抑制肿瘤的作用，这种转录因子可以调控肿瘤细胞的生长。
The present study indicates that interferon can suppress cancer growth by inhibiting expression of a cancer-dependent transcription factor that controls genes that regulate cancer cell growth.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
逆转录多聚酶链反应检测间质胶原酶及金属蛋白酶组织抑制因子- 1基因表达水平。
The gene expression levels for interstitial collagenase and tissue inhibitor of metallo-proteinase-1 (TIMP-1) were measured by reverse transcription polymerase chain reaction.
转录因子NF-IL6特异地在肿瘤组织中过量表达，许多报道表明抑制它的功能对肿瘤治疗有利。
NF-IL6 is specifically overexpressed in tumor tissues. Many reports have shown that abrogation of transcriptional activation activity is useful for tumor therapy.
IRF 4是IRF转录因子家族之一，在免疫细胞上表达，并从不同受体途径激活或抑制基因传导信号。
IRF4, a member of the IRF family of transcription factors, is expressed in cells of the immune system where it transducers signals from various receptors to activate or repress gene expression.
细胞核中，抑制素通过与转录因子如rb和p 53相互作用来调节靶基因的转录(2,5)。
In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription (2, 5).
细胞核中，抑制素通过与转录因子如rb和p 53相互作用来调节靶基因的转录(2,5)。
In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription (2, 5).
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