结果表明，自我失活型逆转录病毒载体能很好地用于衰老基因转录调控的研究。
The results demonstrate that self-inactivating retrovirus vector can be used for gene transcription regulation research during the aging process.
“天地节目”与麻省理工学院的生物学教授进行了对话。这位生物学教授研究的是控制衰老基因序列。
EarthSky spoke to an MIT professor of biology who studies the genetic sequence that controls aging.
哺乳动物包括我们，在这个问题上，我们认为是卡路里的限制作用-一份低能量食物-触发抗衰老基因，可以称之为“sirtuins”（是一种抗衰老酶）。
Lenny Guarente: In mammals, which includes us, what we think is the case, is that calorie restriction - a low calorie diet - triggers anti-aging genes better called sirtuins.
为了论证这点，Baker和van Deursen繁殖了一组具有快速衰老基因的实验鼠，在这个过程中，对实验鼠施以药物刺激，从而清除脂肪组织、肌肉和眼睛中含有P16的细胞。
To accomplish this, Baker and van Deursen designed a fast-aging mouse strain that would, upon receiving a drug trigger, expel p16-producing cells from fatty tissues, muscles and eyes.
科学家将很快能够通过操控人类基因来控制衰老的过程。
Scientists would soon be able to manipulate human genes to control the aging process.
它还控制基因保护细胞不受高活性氧自由基这种被认为通过其在DNA上造成的累积损害导致人衰老的分子的侵害。
It also controls genes that protect cells from highly reactive oxygen radicals - molecules often thought to drive human ageing through the cumulative damage they wreak on DNA.
研究的目的是要确认有关减缓衰老以及避免老年性慢性病的基因。
The goal is to identify genes associated with slowing normal aging and avoiding the chronic illnesses that accompany it.
科学家已经分离出一种看起来能决定人体衰老速度的基因序列。此发现首次将DNA与人类寿命联系起来。
Scientists have isolated a gene sequence that appears to determine how fast our bodies age, the first time a link between DNA and human lifespan has been found.
而且细胞分裂时可能会产生致命的基因复制错误。据此怀疑主义者们说，走向衰老仍是人类不可避免的未来。
Add that to the dangerous genetic copying errors that occur as cells divide and, for these naysayers, growing old remains an unavoidable future for humanity.
基因对于衰老过程有何作用？
整个过程取决于皮肤和韧带的弹性、基因、饮食和正常的衰老过程。
This depends on the elasticity of your skin and of your ligaments, as determined by your genes and diet, and also on normal aging processes.
此项研究显示出了时间性衰老和生物性衰老的区别，其中生物性衰老取决于人体基因组成和生活方式，例如饮食组成和是否吸烟。
The research highlights the difference between chronological age and biological age, the latter of which is determined by our genetic makeup and lifestyle factors, such as diet and smoking.
影响衰老的主要因素有：遗传基因，胚胎发育，教育，阶级属性，事业，生活方式，身份地位，物理和精神状况，社会活动等。
Our genetic inheritance, our quality of life in utero, education, class, career, lifestyle, status, levels of physical, mental and social activity are just some of the main influences.
科学家希望通过研究布鲁克的基因，他们可以知道衰老的过程的奥秘，甚至可以发明出新的治疗和老年病有关的治疗方法。
It is hoped by analysing Brooke's DNA, scientists could gain a fresh insight into the process of ageing and even develop new therapies and treatments for diseases linked to old age.
他表示，如果研究结果显示这并不与特定疾病相关，而却在全球有更广泛的影响，这将表明此类基因也许对延缓衰老起到基础性作用。
If it turns out there's no disease-specific relationship, but instead a more global influence, that would suggest these genes may have a fundamental role in slowing the aging process, he said.
科学家们开始让基因工程小鼠的衰老细胞中有一个特定的分子。
The scientists started by genetically engineering mice to have a specific molecule in their senescent cells.
如果我们把她的染色体组合正常的染色体比较的话，我们有可能会发现不同的基因，从而发现基因的功能，从而找出对抗衰老的方法。
If we can compare her genome to the normal version then we might be able to find those genes and see exactly what they do and how to control them.
它们也具有基因多样化，来确保老鼠死于不同的方法，这就要求任何潜在抗衰老药物有一个真正的广泛影响。
They were also genetically diverse, ensuring that mice would die in many different ways, and requiring any potential anti-aging drug to have a truly broad effect.
很多生物学家仍认为停止衰老只是一个幻想，因为我们永远不能克服细胞过段时间就会死亡，以及基因组的消耗磨损等生物程序。
Plenty of biologists still say it's a mirage because we will never overcome the biological programme whereby cells die after a certain time, or indeed the rigours of wear and tear on the genome.
吸烟、衰老、压力、大气污染、我们的饮食及许多其他环境因素都能对表观基因组造成破坏。
The epigenome can be disrupted by smoking, ageing, stress, atmospheric pollution, what we eat and drink, and a host of other environmental factors.
总有一天，数据会带来基因测试的进展，从而可预测一个人是否能预期长寿，并对衰老相关疾病防治的干预措施提供指导。
And one day the data might lead to the development of genetic tests to predict whether a person can expect to live into old age as well as guide intervention efforts to prevent age-related illness.
我们推测SPATA4基因极有可能参与到细胞衰老乃至个体衰老的过程中。
We postulate that SPATA4 gene is very likely to be involved in the process of cellular senescence and aging.
这项研究是美国国家衰老研究所试验项目的一部分，美国3个机构的科研人员分别进行了这项实验，用到了2000多只基因相似的实验鼠。
The research, conducted as part of the National Institute of Aging Interventions Testing Program, took place at three separate test sites and involved nearly 2, 000 genetically similar mice.
为了更加深入地了解衰老过程中的千差万别，一个由英国和荷兰研究人员组成的团队比对了50多万份人类基因组资料。
To better understand the aging discrepancy, a team of researchers in Britain and the Netherlands scanned more than 500, 000 genetic variations across the human genome.
为了更加深入地了解衰老过程中的千差万别，一个由英国和荷兰研究人员组成的团队比对了50多万份人类基因组资料。
To better understand the aging discrepancy, a team of researchers in Britain and the Netherlands scanned more than 500, 000 genetic variations across the human genome.
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