研究了在稀碱催化下邻羟基苯乙酮和苯甲醛在乙醇溶液中的羟醛缩合反应,溶剂可以循环使用,适合工业化生产。
During the condensation reaction, the feedstock remaining after reaction can be recycled, and this synthesis route was suitable for the commercial production.
前言:以2′,5′-二羟基苯乙酮和原甲酸三乙酯缩合得到6- 羟基- 4- 色酮,再经催化氢化得到标题化合物。
6-Hydroxychroman was prepared by catalytic hydrogenation of 6-hydroxy-4-chromone, which was prepared via condensation of 2′, 5′-dihydroxyacetophenone with triethyl ortho-formate.
采用新方法合成了鲜见文献报道的新化合物2 -羟基-3-氰甲基-5 -甲基苯乙酮。该方法具有反应时间短、操作简便、收率好等优点。
Using the new method, 2 hydroxy 3 cyanmethyl 5 methyl acetophenone was synthesized in a short reaction period, and the yield was good.
羟基处于醛基邻位和对位的苯甲醛与几种苯乙酮衍生物的缩合,多数没有得到预期的产物,或收率极低;苯乙酮环上的羟基对缩合反应影响很大,羟基越多,缩合越困难。
The groups in ring of benzaldehydes, no matter they are electron withdrowing or electron donating except of hydroxy, do not seem to have much effect on the yield.
羟基处于醛基邻位和对位的苯甲醛与几种苯乙酮衍生物的缩合,多数没有得到预期的产物,或收率极低;苯乙酮环上的羟基对缩合反应影响很大,羟基越多,缩合越困难。
The groups in ring of benzaldehydes, no matter they are electron withdrowing or electron donating except of hydroxy, do not seem to have much effect on the yield.
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