结论：长期服用罗非昔布对大鼠骨关节病关节软骨的胶原代谢无明显影响。
Conclusion: Rofecoxib administrated for a long term has no harm influence on the collagenic metabolism of the rats' knee joints cartilage in experimental osteoarthrosis.
使用罗非昔布并且有心梗病史的患者心梗发生率为1.59%，而没有心梗病史的患者心梗发生率只有1.23%。
The MI rate ratio with rofecoxib use was 1.59 in patients with a prior MI and 1.23 in those without a previous MI.
使用罗非昔布并且有心梗病史的患者心梗发生率为1.59%，而没有心梗病史的患者心梗发生率只有1.23%。
The MI rate ratio with rofecoxib use was 1.59 in patients with a prior MI and 1.23 in those without a previous MI.
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