结论：四环素调控白喉毒素A基因对肺腺癌有一定的治疗作用。
Conclusion: DTA gene regulated by tetracycline has therapeutic effects on lung adenocarcinoma.
目的表达白喉毒素无毒变异体CRM197，并考察其载体作用。
Objective To express the nontoxic mutant CRM197 of diphtheria toxin and study its effect as a carrier protein.
结论体外转染白喉毒素a基因可杀伤人肺腺癌细胞并降低人肺腺癌细胞的致瘤性。
Conclusion: Transfection of DTA gene in vitro may kill human lung adenocarcinoma cells and reduce the oncogenicity of human lung adenocarcinoma cells.
提示细胞壁缺陷变异可影响白喉棒状杆菌产生白喉毒素蛋白质，从而使其丧失了产生外毒素致病的作用。
And no diphtherotoxin was detected in its soluble metabolites indicating that cell wall defect might affect the production of diphtherotoxin, therefore lost its pathogenic role in exotoxin production.
目的探讨重组白喉毒素-人白细胞介素13嵌合毒素dt389 - IL 13对胶质瘤细胞的杀伤作用机制。
Objective to explore the cytotoxic mechanism induced by recombinant chimeric toxin DT389-IL13. Methods U251 cells were incubated with recombinant chimeric toxin DT389-IL13 at different concentrations.
目的探讨重组白喉毒素-人白细胞介素13嵌合毒素dt389 - IL 13对胶质瘤细胞的杀伤作用机制。
Objective to explore the cytotoxic mechanism induced by recombinant chimeric toxin DT389-IL13. Methods U251 cells were incubated with recombinant chimeric toxin DT389-IL13 at different concentrations.
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