目的：介绍白三烯抑制剂治疗哮喘的进展。
OBJECTIVE:To review the progress of leukotriene inhibitors in the treatment of asthma.
结论：白三烯受体拮抗剂在治疗哮喘患儿中起抗炎作用。
Conclusion: Leukotrienes receptor antagonist had anti-inflammatory effect in the treatment of asthma.
白三烯a 4水解酶和脑细胞降解产生的脑啡肽的抑制剂。
Inhibitor of leukotriene A4 hydrolase and of enkephalin degradation in cell preparations from brain.
目的研究白三烯受体拮抗剂-扎鲁司特对运动性哮喘的治疗作用。
Objective Zafirlukast, leukotriene receptor antagonist, is introduced in this study to investigate its effect on exercise induced bronchospasm.
结论：白三烯抑制剂临床使用安全有效，是一类新的哮喘治疗药物。
CONCLUSION: Leukotriene inhibitors is safe and effective in clinical use and may be as an new agent in the...
前列腺素和白三烯是重要的免疫功能，平滑肌功能，血小板聚集和炎症。
Prostaglandins and leukotrienes are important in immune function, smooth muscle function, platelet aggregation and inflammation.
孟鲁司特，选择性白三烯受体1拮抗物，能减少雨蛙肽诱导的胰腺损害。
Montelukast, a Selective Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces Cerulein-Induced Pancreatic Injury in Rats.
目的探讨白三烯B4在慢性荨麻疹发病中的意义及咪唑斯汀在治疗慢性荨麻疹中的抗炎作用。
Objective To explore the role of leukotriene B4 in the pathogenesis of chronic urticaria and the anti-inflammation activity of mizolastine in treating chronic urticaria.
结论短期应用白三烯受体拮抗剂可改善哮喘患者乙酰甲胆碱支气管激发试验剂量-反应曲线参数。
Conclusion Short term use of Zafirlucast in asthmatic patients could improve the parameters of dose response curve obtained after the methacholine challenge test.
目的探讨呼吸道合胞病毒(RSV)毛细支气管炎患儿尿白三烯e4 (LTE4)测定的临床意义。
Objective to explore the clinical significance of urinary leukotriene E4 (LTE4) detection in children with respiratory syncytial virus bronchiolitis (RSV).
我们假设多药抗药性相关蛋白-1介导的白三烯C4内位-外位转运是致血管系统动脉粥样硬化的重要机制。
We hypothesize that inside-outside transport of leukotriene C4 (LTC4) via MRP1 is a substantial proatherogenic mechanism in the vasculature.
初步药理结果表明化合物（51），（68），（89）和（95）对白三烯D_4受体有较好的拮抗作用。
Pharmacological tests showed that compounds (51), (68), ( 89) and (95) have strong antagonism on the D4 recepter of Leukotriene (LTD4).
方法采用反相高效液相色谱法检测5-脂氧合酶产物——白三烯B4和5-羟花生四烯酸量的变化来反映该酶活性的改变。
Methods 5- LO products, leukotriene B4 (LTB4) and 5 hydroxyeicosatetraenoic(5-HETE), we re determined by RP-HPLC to represent 5-LO activity.
目的探讨白三烯（LT）B4能否不依赖细胞核因子资B受体激活剂配体（RANKL）直接促进人破骨细胞的分化和激活。
Objective To determine whether leukotriene B4 (LTB4) could directly stimulate human osteoclast differentiation and activation independent of RANKL (ODF).
目的探讨了血清可溶性白细胞介素-2受体（SIL-2R）和半胱氨酰白三烯（LTS）水平在支气管肺炎患儿治疗前后的变化及意义。
Objective To investigate the significance of changes of serum SIL-2R and cysteine LTS levels after treatment in pediatric patients with bronchopneumonia.
结论—这些研究结果表明多药抗药性相关蛋白-1和白三烯C4都有致动脉粥样硬化作用，因此两者都有可能成为抗动脉粥样硬化治疗的靶向物质。
Conclusions-: These findings indicate that MRP1 and LTC4 exert proatherosclerotic effects and that both MRP1 and LTC4 are potentially promising targets for atheroprotective therapy.
花生四烯酸代谢产物白三烯B_4与炎症及过敏反应中白细胞的各种活动密切相关。筛选有效的白三烯B_4抑制荆可为临床提供抗炎抗过敏反应的一代新药。
LTB4 is one of the metabolites of arachidonic acid via 5-Hpoxygenase pathway. lt is a potent inflammatory mediator and is related to actions of leukocytes in hypersensitive reactions.
花生四烯酸代谢产物白三烯B_4与炎症及过敏反应中白细胞的各种活动密切相关。筛选有效的白三烯B_4抑制荆可为临床提供抗炎抗过敏反应的一代新药。
LTB4 is one of the metabolites of arachidonic acid via 5-Hpoxygenase pathway. lt is a potent inflammatory mediator and is related to actions of leukocytes in hypersensitive reactions.
应用推荐