肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
从宇宙射线到辐射到日常饮食，任何东西都可能激活潜伏的致癌基因。
Anything from cosmic rays to radiation to diet may activate a dormant oncogene.
MGMT基因的失活常导致原癌基因的激活。
The inactivation of MGMT gene may urge the proto oncogene activation.
越来越多的证据表明，肿瘤的发生是多因素作用的结果，与癌基因的激活与抑癌基因的失活有关。
More and more evidence indicated that the formation of tumor is due to multi factors with oncogene activation and anti oncogene inactivation.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
从宇宙射线、辐射到日常饮食，任何东西都可能激活一个处于静止状态下的致癌基因，但如何激活尚不为人知。
Anything from cosmic rays to radiation to diet may activate a dormant oncogene, but how remains unknown.
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
BRAF癌基因突变的激活是皮肤黑色素瘤最常见的基因改变。
Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma.
一般情况下，它们都处于封存不动状态，但在特殊情况下，原癌基因被激活或抗癌基因丢失，人就会患上癌症。
Under normal circumstances, they are sealed in a fixed state, but in exceptional circumstances, the proto-oncogenes or tumor suppressor genes are activated is lost, people will suffer from cancer.
癌基因的激活以及抑癌基因的失活被认为与细胞的恶性转化密切相关。
Transformation of cells is closely related to the inactivation of tumor-resistant genes and the activation of oncogenes.
如果几个致癌基因被激活，不能不他们除掉的话，细胞就癌变了。
If several oncogenes are driven into action, the cell, unable to turn them off, becomes cancerous.
如果几个致癌基因被激活，不能不他们除掉的话，细胞就癌变了。
If several oncogenes are driven into action, the cell, unable to turn them off, becomes cancerous.
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