核酶是一类具有催化功能的核酸分子。
理想的核酶应满足高效、特异、稳定的要求。
The ideal ribozyme should satisfy with requires of highly catalytic efficiency, well specificity and stabilization.
在该项目中，我们试图筛选出各种存在的核酶。
In this project we are screening the kingdom of life for the presence of ribozymes.
设计针对端粒酶的HDV核酶，观察其对端粒酶活性抑制。
To design HDV ribozyme for human telomerase RNA( hTR) component, and observe its inhibition for telomerase activity. Pseudoknotted g.
设计针对端粒酶的HDV核酶，观察其对端粒酶活性抑制。
To design HDV ribozyme for human telomerase RNA (hTR) component, and observe its inhibition for telomerase activity. Pseudoknotted g.
我们同时包含了人工设计的一些核酶，以便找出是否存在天然的同型物。
We also include artificially designed ribozymes in order to find out whether natural analogs exist.
在锤头型核酶下游增加一段核酶作用的靶序列，使之成为自切割的核酶。
A self cleaving ribozyme was comprised of a hammerhead ribozyme and its target sequence located the downstream of the hammerhead ribozyme.
目的：探讨JWA核酶基因转染对肺动脉平滑肌细胞表型及迁移的影响。
AIM: To investigate the effects of transfected JWA ribozyme gene on phenotype and migration of human pulmonary artery smooth muscle cells (PASMCs).
这样一来，细胞内部发生的使得核酶加速核酸复制速率的任何变化，都会在进化群体中快速扩散。
Thus, any random changes in the interior, fledgling ribozymes that could speed up nucleic acid replication rates will spread rapidly through an evolving population.
结论载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白d1的表达和激活。
Conclusion Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line.
萧斯泰克已经做出了一系列的“核酶”，因为已知有催化效用的RNA在发挥作用，而且有一些需要AT P提供能量。
Dr Szostak has already made a range of "ribozymes", as catalytic pieces of RNA are known in the trade, and some of them are ATP-powered.
目的检测犬贾第虫病毒介导的锤头状核酶对犬贾第虫滋养体核仁功能性蛋白krr1基因体外转录体切割效率。
Objective to detect the cleavage activity of Giardia Canis virus (GCV) transfer vector-mediated hammerhead ribozyme for KRR1 in vitro transcript.
这种CCR5核酶分子能中止了病人的白血细胞产生CCR5，后者是艾滋病毒用于进入宿主细胞的一种蛋白质。
The CCR5 ribozyme molecule stops the patient's white blood cells producing CCR5, a protein that HIV USES to get into host cells.
通过对它的研究，人们发现并且掌握了核酶的分子机制、RNA的自我拼接、端粒的结构和功能、DNA序列重组等机理。
Some investigations on the ciliated protozoan have provided the insights into the mechanism of ribozymes, self-splicing RNA, telomere structure and function, DNA sequence reorganization and so on.
对天然核酶的改造和人工核酶的筛选使核酶的催化反应谱得到了扩展，也为核酶作为基因治疗药物和核酸探针提供了多种选择。
Its catalytic repertoire expanded by modification and in-vitro-selection of nucleic acid libraries endows ribozymes a great potential as gene therapeutic agents and nucleic acid probes.
概述了脱氧核酶的结构特点、修饰和设计策略、催化特点、在基因治疗中的优势及作为一种新型的基因治疗工具在肿瘤治疗中的应用。
This article introduced the DNAzyme in such spects as structures, modifications, designing strategies, catalytic traits, advantages as well as its application as a new tool of gene therapy of tumor.
设计合适的核酶分子能够阻断癌基因的异常表达，逆转肿瘤细胞MDR，促进肿瘤细胞凋亡，有望成为肿瘤基因治疗的有效手段之一。
With appropriate designing, it could block oncogene's expression, reverse MDR, and promote tumor cell apoptosis. All these properties make the Ribozymes as potentially useful regent for gene therapy.
设计合适的核酶分子能够阻断癌基因的异常表达，逆转肿瘤细胞MDR，促进肿瘤细胞凋亡，有望成为肿瘤基因治疗的有效手段之一。
With appropriate designing, it could block oncogene's expression, reverse MDR, and promote tumor cell apoptosis. All these properties make the Ribozymes as potentially useful regent for gene therapy.
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