组蛋白 H3与H2A，H2B，H4 共同构成了真核生物核小体的八聚体核心。
Histone H3 along with H2A, H2B, and H4 form the eukaryotic nucleosome octamer core.
RNA的合成在核小体上进行。
核小体；肺癌；化疗；预测；监测。
Nucleosomes; Lung cancer; Chemotherapy; Prediction; Monitoring.
核小体是染色质的基本单位。
抗核小体抗体；系统性红斑狼疮；elisa。
一种组蛋白的八聚物把DNA打包成一种叫做核小体的结构。
An octa-mer of histones package DNA into a structure called a nucleosome.
用这个技术，总的染色质首先被切成单个核小体大小的片断。
With this technique, total chromatin is first cut into single nucleosome-sized pieces.
核小体串珠压缩整合而成的一种纤维结构，形成染色质结构的功能单位。
Solenoid --- A fiber composed of compacted strings of nucleosomes, forming the fundamental unit of chromatin organization.
研究人员怀着了解两种不同的甲基化标记怎样影响核小体和染色质结构的目的开始工作。
The researchers began their work with the goal of learning how two different methylation marks affect the overall structure of nucleosomes and chromatin.
这些修饰调控组蛋白- DNA相互作用，为核小体迁移的表观遗传调控添加了新的维度。
These modifications regulate histone-DNA interactions, adding a new dimension to the epigenetic regulation of nucleosome mobility.
人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。
It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
核小体有着葡萄状结构，由葡萄藤样的DNA链环绕组蛋白所形成，其作用是组织极长的DNA分子。
Nucleosomes are grape-like structures formed by strands of DNA wrapped like vines around histone proteins, and serve to organize enormously long DNA molecules.
组蛋白H3与其他类型的组蛋白分子H2A，H2B，H4共同构成了真核生物核小体的八聚体核心。
Histone H3 is one of the four histones, along with H2A, H2B, and H4, which form the eukaryotic nucleosome octamer core.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.
DNA作为生命的遗传蓝图，必须被解码或被“阅读”，甚至在被紧密“打包”放进核小体的时候也是如此。
As the genetic blueprint of life, DNA must be deciphered or "read," even when densely packed into nucleosomes.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
因此核小体是细胞内遗传过程的一个关键靶标，也是解密正常与异常细胞工作方式的科学探索活动的一个焦点。
The nucleosome is therefore a key target of genetic processes in a cell and a focus of scientific investigations into how normal and diseased cells work.
利用这种新型工具，Luger和他的同事进行了X射线晶体学和生物物理学研究，来看甲基化怎样影响染色质和核小体结构。
With this new set of tools, Luger and her colleagues did X-ray crystallographic and biophysical studies to see how methylation affects the structure of chromatin and nucleosomes.
但是有趣的问题是它们是否随着甲基化发生动态变化——个体核小体是否有会有更大的倾向来解开，拆开染色质，还是仅仅被改型。
But the interesting question will be whether their dynamics change with methylation-whether individual nucleosomes may have a higher propensity to unfold, to unravel slightly or just to be remodeled.
核小体核心由140个碱基对的DNA围绕一个组蛋白小球组成，每一个组蛋白小球包含两个H_2A、H_2B、H3和H4的四聚体分子。
The core consists of 140 base pair of DNA wrapped around a globular histone bead containing two each of histones H2A, H2B, H3 and H4.
真核细胞中，核小体是染色质的基本单位，它由两个拷贝HA、HB、H和H所组成的核心组蛋白八聚体，及缠绕于其上的bpDNA构成。
In eukaryotic cells, the fundamental unit of chromatin is nucleosome, which is composed of a histone octamer with two copies of HA, HB, H and H and base pairs of DNA.
细胞表现为细胞皱缩、核质浓缩、核碎裂、细胞起泡以及凋亡小体形成等凋亡特征的形态学改变。
Apoptosis with nuclear chromatin condensation and fragmentation as well as cell shrinkage and the formation of apoptotic bodies were observed.
在此基础上对凋亡小体结构在形成及排出核外的过程进行了详细的观察和分析。
Then we took a deeper look into the process how the apoptotic bodies were formed and tried to vivify the formation.
结果显示：肿瘤细胞皱缩出芽、核裂解及凋亡小体形成。
The results showed that the retraction, budding, nuclear fragmentation and the formation of apoptotic bodies were apparent.
细胞核形成凋亡小体并最终解体。
The nuclear comes into being apoptosis body and disaggregates at last.
NBT还原实验发现部分早幼粒白血病细胞胞奖内出现紫蓝色颗粒，并见到核碎解成染色质小体（凋亡小体）。
Part of the acute promyelocytic leukemia cells appeared indigo granules and apoptosis body in plasma through NBT test.
视野中心部分的RBC含有几个Howell - Jolly小体或残余的核染色质内容物。
The RBC in the center of the field contains several Howell-Jolly bodies, or inclusions of nuclear chromatin remnants.
出现可染小体巨噬细胞，未见明显核仁或不规则核形。
Tingible body macrophages are present. No prominent nucleoli or irregular nuclear profiles are appreciated.
出现可染小体巨噬细胞，未见明显核仁或不规则核形。
Tingible body macrophages are present. No prominent nucleoli or irregular nuclear profiles are appreciated.
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