来自AT病人的细胞显示有缺陷的DNA损伤诱导检验点激活，对放射的敏感性和频率较高的染色体断裂(3,4)。
Cells from at patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage (3, 4).
双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。
If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.
每次分裂后，端粒变短一段时间后可能发生的一件事是染色体上的基因片段会断裂。
So after each division, the telomeres get shorter and one of the things that may happen after a while is that pieces of the genes themselves get broken off the Chromosomes.
当每次染色体分裂时——即当每次一个细胞分裂成两个时——染色体的尾部，也就是端区，就会发生断裂。
Every time the Chromosome divides—every time one cell divides into two—pieces of the ends of the Chromosome, the telomere, get broken off.
由NEU所诱发的染色体初级断裂不能为连接酶所修复。
Thus, the NEU-induced primary chromosome breakage may not be repaired by the ligase.
另外，辐射所致染色体的断裂和重排对癌基因和其他相关基因的移位和失调可能起着重要作用。
Otherwise, the chromosome break and rearrangement induced by radiation maybe play important pole in leading to the translocation and misalignment of cancer genes and other correlated genes.
紫杉醇还能抑制有丝分裂所需的微管网再生，妨碍有丝分裂纺锤体的形成导致染色体的断裂，抑制了肿瘤细胞的复制。
Taxol can inhibit mitosis of the microtubule network renewable, prevent mitotic spindle lead to the formation of chromosome break, inhibit the replication of tumor cells.
此外，外界因素，如电离辐射和某些化学药物等因素使DNA双链断裂，也可能导致染色体转位和癌变。
Moreover, exogenous agents, such as ionizing radiation and some chemicals can result in chromosome translocation and tumorigenesis because of their role on induction of DNA double strand breaks.
大多数的缺失可能是由于发生了两个断裂，而两个断裂之间的那部分染色体物质失去了。
Most deletions are likely to be the result of two breaks with loss of the chromosomal material between them.
目的对医用诊断X射线工作者染色体畸变断裂点的分布进行分析。
Objective To analyze the distribution of the chromosome aberration breakpoints from medical diagnostic X-ray workers.
钬离子诱导蚕豆根尖细胞染色体畸变和微核产生的分子机制主要为DNA断裂作用。
The molecular mechanism for chromosomal aberration and micronuclei induced by holmium ions was most probably DNA breakage to root-tip cells of vicia faba.
结果表明：DCAP是一种染色体损伤剂，诱发的畸变主要为染色单体断裂和交换；
Results showed that DCAP was clastogen and the aberrations were mainly chromatid breaks and exchanges.
虽然对染色体上断裂点多发部位的真正生物学意义尚不清楚，但可以肯定的是有关损伤热点的研究是辐射远后效应研究中十分重要的一部分。
Although the true biological significance of break point regions has been not clear, there is no doubt that research on hot damage point is important part of study on after effect of radiation.
方法：采用低叶酸tc 199培养诱导法，对80名孤独症儿童和80名正常儿童进行了外周血淋巴细胞染色体脆性位点表达检测和断裂点频率统计。
Method: Chromosome fragile sites and breakpoint expression by reducing folacin in TC199 medium were determined in 80 autistic children and 80 normal children.
由于电离辐射引起的断裂造成的染色体畸变。
Study on Ionizing Radiation to the Workers′ Lymphocyte Micronucleus Rate and Chromosome Aberrations. ;
由于电离辐射引起的断裂造成的染色体畸变。
Study on Ionizing Radiation to the Workers′ Lymphocyte Micronucleus Rate and Chromosome Aberrations. ;
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