病理学：p53肿瘤抑制基因突变，第11p15基因座杂和性丢失。
Pathology: p53 tumor suppressor gene mutation, loss of heterozygosity (LOH) at 11p15 locus. PAX-FKHR gene fusion.
氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤；
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
该药物能够准确的将正确的染色体数目导入每一新细胞，产生非整倍体细胞，能够用于治疗由于肿瘤抑制基因突变导致的肿瘤。
Drugs that inhibit accurate delivery of the right number of chromosomes to each new cell, resulting in aneuploidy, would be used to destroy tumors caused by mutations in the tumor suppressors.
“从不吸烟的患者对一类叫表皮生长因子受体抑制剂的药物反应更好，因为这类患者有表皮生长因子受体基因突变的可能性更大一些。”鲁丁说。
"Patients who never smoked respond better to a certain class of drugs called EGFR inhibitors, because lung cancer in these patients more often contain mutations in the EGFR gene," Rudin says.
其他的基因突变可以抑制肿瘤，是人体对抗因基因突变而产生危险的天然防御机制。
The other mutated genes seemed to be tumor suppressors, the body's natural defense against dangerous genetic mistakes.
NF 1基因突变导致肿瘤抑制异常，可发生各种各样的良性和恶性肿瘤。
The genetic mutation of the NF1 leads to abnormal tumor suppression, leading to a variety of benign and malignant tumors.
目的：探讨蜂胶对环磷酰胺等强诱变剂诱发基因突变的抑制作用。
Objective: To study the effects of propolis against gene mutation induced by powerful mutagens in mice.
KRAS基因突变在恶性肿瘤组织中频发，可预测非小细胞肺癌分子靶向治疗的疗效和预后，针对RAS基因的分子抑制剂研究仍处于初级阶段。
KRAS mutation frequency in tumor tissue, can be predicted non-small cell lung cancer molecular targeted therapy efficacy and prognosis, and molecular inhibitors of RAS genes is still in its infancy.
这种互相作用，不象是环境(细胞质)中某些因素引起基因突变或基因的活化和抑制。
It does not seem that in this interaction some factors of environment (cytoplasm) lead to the gene mutation or the activation and check of the gene.
PTEN肿瘤抑制因子在乳腺癌中虽常呈失表达，但并不是通过基因突变或促进子甲基化而实现的，因此其失表达的机制还不清楚。
Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms.
研究者们希望，通过对该基因突变和相关蛋白结构的深入了解可以开发出有效的药物治疗来抑制突变基因的激活。
The researchers hope that understanding more about the gene's mutations and the structure of the protein may lead to drug treatments to help ensure that mutant copies of the gene are inactive.
不同的基因突变改变了功能或活动的一个基因，它可以抑制一种非常合适的药物，失去了基因树叶什么药物目标。
Unlike a genetic mutation that changes the function or activity of a gene, which can be inhibited by a well-tailored drug, loss of a gene leaves nothing for the drug to target.
FBW7是一种肿瘤抑制蛋白，其基因在多种肿瘤包括直肠癌、胃癌、卵巢癌和白血病中存在着基因突变或缺失。
FBW7 is a tumor suppressor, and its gene is frequently mutated or deleted in various human cancers including colorectal, gastric, ovarian and leukemias.
FBW7是一种肿瘤抑制蛋白，其基因在多种肿瘤包括直肠癌、胃癌、卵巢癌和白血病中存在着基因突变或缺失。
FBW7 is a tumor suppressor, and its gene is frequently mutated or deleted in various human cancers including colorectal, gastric, ovarian and leukemias.
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