目的阐明手性和药物手性的概念及其研究的实际意义。
Objective: Expound chirality with chiral drugs concept and actual meaning of research.
在TANK正准备引怪是加盾是新手性的错误,而且我们并不打算去修正它。
Shielding the tank right as he's pulling is a rookie mistake, and we're not really trying to "fix" that.
可是,在生物化学界占支配地位的酶,恰恰是这样一种往往只能接受某一手性的精密工具。
But the enzymes that govern biochemistry are such precise tools that, often, only one-handedness is acceptable.
比如说,几乎所有构成生物蛋白的氨基酸都是左手性的,所以出现右手手性的自我复制生物分子可能意味着发现了外星生物体。
Almost all amino acids that make up biological proteins, for instance, are left-handed, so a self-replicating biological molecule of right-handed chirality could be suggestive of an alien organism.
“许多药物分子是手性的,并且两种镜象结构在药理上(pharmalogically)有所区别,对人体的作用是不同的”,科恩说。
"Many drug molecules are chiral and the two mirror images are pharmalogically different and do not have same interactions with the body," says Cohen.
通过磷酰氯与手性仲胺的亲核取代反应高产率地合成了手性HMPA 类似物。
The chiral HMPA analogues were prepared in high yield by nucleophilic substitution between the chiral secondary amine and phosphoryl chloride.
研究了重氮烯氢向前手性烯烃单侧的非对映选择性转移。
Diastereoselective transfer of the diazene hydrogen to one face of the prochiral alkene was studied.
可用于合成各种具芳基胺醇类结构的手性药物。
It can be oriented to produce levo-aromatic and dextro-aromatic alcohols.
早期的地球似乎是被一层并不存在手性偏好的有机分子汤所覆盖。
Early Earth seems to have been covered in a soup of organic molecules with no chiral preference.
但他确实认为可能发现其他的手性结构来应用于自旋电子学应用中,前提是确认手征性就是自旋过滤发生的机制。
But he does think that other chiral structures could find application in spintronics - if chirality is found to be the mechanism behind the filtering, that is.
此外,如果一个分子有很多的手性中心,每一个都能起作用,那么所需分子结构的产量就会很少。
Moreover, if there are lots of chiral centres in a molecule, and each matters, the yield of the version with the right combination can be minuscule.
脂肪酸没有手性;它们的镜像分子就是自己。
The fatty acids have no chirality; their mirror image is the same molecule.
他表示,以科学工作者秉承的谨慎态度来看,很难想象完全以手性反转分子结构形成的镜像细胞会成为现实。
The cautious scientist in him can’t see how the mirror cell, once full of chirally flipped molecular machinery, will come to life.
这种细胞的生物化学运作过程和普通生命完全一样——从DNA到RNA再到蛋白质,但它与手性对应的地球生命可能完全不相容。
Its biochemistry would work just like ours-dna to RNA to proteins-but it would be completely incompatible with earthly life, its chiral twin.
但问题在于丘奇的实验室与正常的手性设定是匹配的。
The problem for now is that Church's entire lab is tuned to the wrong chiral setting.
以镜像方式对称的分子通常会具有不同的性质,于是研究人员利用这种“手性(chirality,译注:指分子的左/右手螺旋性质)”来设计新药物。
Molecules often come in mirror images that can have different properties, and researchers take advantage of this "chirality" to design new drugs.
“偏手性有基因基础,但是同人的其他特征——如身高、体重——一样,十分复杂,”他说,“单独一个基因并不能导致它,环境因素在其中也有很大作用。”
"Handedness has a genetic basis, but like other complex traits - height, weight - it is complex," he said. "it's not a single gene that leads to it."There's a strong environmental component, too.
“偏手性有基因基础,但是同人的其他特征——如身高、体重——一样,十分复杂,”他说,“单独一个基因并不能导致它,环境因素在其中也有很大作用。”
"Handedness has a genetic basis, but like other complex traits - height, weight - it is complex," he said. "it's not a single gene that leads to it." There's a strong environmental component, too.
为了形成这种光束,他们将一束右手性绿色激光束照射在反射镜上,并使原光束与其反射的左手性光束相互作用。
To make it, they shone a right-handed green laser beam at a mirror and let it interact with the left-handed reflection.
他计划去创造一种不但能阅读寻常rna转录体同时又能将错误手性氨基酸串联起来形成镜像蛋白的核糖体。
His plan is to make one that reads regular RNA transcripts of genes but can string together wrong-handed amino acids to form mirror proteins.
旋转偏振光被他们用来筛选左手性和右手性分子,这种光的电场以左手或右手螺旋形式在空间旋进。
They sort left from right versions using circularly polarised light, whose electric field corkscrews through space in a left or right-handed direction.
在生物化学中,手性是有意义的,如左旋和右旋的物质气味可能不同。
In biochemistry, handedness can matter. Left - and right-handed versions may, for example, smell different.
但是,偏手性始终是个谜。它的比例——人群中大约90%是右手使用者,10%是左手使用者——始终保持不变。
But the riddle of what underlies handedness remains. Its proportions - roughly 90 percent of people are right-handed and 10 percent left-handed - stay consistent over time.
这就是为什么分别生产两种手性形式是极其重要的。
That is why it is vital to be able to produce the two chiral forms separately.
当有朝一日国家主义的主张或反诉回漾在冰川之上时,这一地区问题的刺手性仍将迫使那些自诩的征服者们勉强共处。
At a moment when nationalistic claims and counter-claims are resounding over the ice-floes, the region's intractability still forces its would-be conquerors to rub along.
实际上,根据Naaman的解释,在手性分子蒸气过程中起作用的主要是自旋—轨道耦合相互作用,这显然太弱而无法解释当前的实验结果。
As a result the interaction at work in the vapour - spin-orbit coupling - is simply too weak to explain these recent results, according to Naaman.
实际上,根据Naaman的解释,在手性分子蒸气过程中起作用的主要是自旋—轨道耦合相互作用,这显然太弱而无法解释当前的实验结果。
As a result the interaction at work in the vapour - spin-orbit coupling - is simply too weak to explain these recent results, according to Naaman.
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