结论：儿童静脉慎用头孢拉定。
CONCLUSION: Intravenous administration of cefradine in children should be very careful.
目的监测头孢拉定对肾脏的不良反应。
Objective the ADRs of cefradine to the kidney were monitored.
目的对国产头孢拉定的质量现状进行评价。
Objective To evaluate the quality of cefradine preparations at present.
结论：两种头孢拉定胶囊具有生物等效性。
CONCLUTION: The two cephradine capsules were of bioequivalence.
目的：考察几种市售头孢拉定胶囊剂的质量。
Objective: To evaluate the quality of several cefradine capsules sold on the market.
建立一种HPLC法快速测定头孢拉定血清浓度。
To establish a simple HPLC column switching method for measuring cefradine in human serum.
结果与结论大剂量或长期应用头孢拉定对肾脏有毒性。
Results and Conclusions Using cephradine by high-dose or long-term is toxic to the kidney.
结果：头孢拉定胶囊的高分子杂质含量均小于0.5%。
RESULTS: The content of high molecular weight impurities in Cephradine Capsule is less than (0.5) %.
结果：adr涉及药品排前3位的是头孢噻肟、头孢拉定和头孢曲松。
Results: Top 3 drugs related to ADR were cefotaxime, cefradine and ceftriaxone.
方法：按药典方法对5厂家效期内13批次的头孢拉定胶囊剂进行检测。
Methods: 13 different batches of cefradine capsules manufactured by 5 factories, were evaluated according to the Chinese Pharmacopoeia.
目的：探讨头孢拉定（CED）所致不良反应的特点，促进临床安全用药。
OBJECTIVE: To discuss the features of adverse drug reaction(ADR) induced by cefradine(CED) in order to promote the safe drug use in clinic.
方法通过对文献检索和筛选，分析头孢拉定肾脏不良反应的原因，总结转归及预防。
Methods Through literature search and selection, the causes of renal ADRs of cephradine were analyzed, and preventive measures were recommended.
方法：对现行版药典中的头孢拉定及其制剂的有关物质检查方法进行比较和实验观察。
Methods: according to the comparison and test observation on the different methods for examination of rs in cefradine and its preparation collected in the pharmacopoeias in use.
超细头孢拉定混悬剂也显示了很好的沉降效果，说明超细头孢拉定在注射剂和混悬剂两种剂型上有很好的应用前景。
Furthermore, the sedimentation experiment showed the good effect of the ultrafine cefradine suspension. This would find wide applications in ultrafine cefradine injection and suspension in future.
超细头孢拉定混悬剂也显示了很好的沉降效果，说明超细头孢拉定在注射剂和混悬剂两种剂型上有很好的应用前景。
Furthermore, the sedimentation experiment showed the good effect of the ultrafine cefradine suspension. This would find wide applications in ultrafine cefradine injection and suspension in future.
应用推荐