目的是探讨外排泵在嗜麦芽窄食单胞菌中对氟喹诺酮类药物的耐药性中的作用。
The objective is to explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia.
应用外排泵抑制剂利血平后，70%诱导耐药菌mic有明显下降。
MIC was decreased by inhibitory of efflux pump in 70% resistant bacteria.
目的：探讨主动外排泵在嗜麦芽寡养单胞菌对氟喹诺酮类药物耐药中的作用。
Objective:To explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia.
抗菌药物耐药机制包括：(1)靶位修饰；(2)产灭活酶；(3)药物渗透力下降；(4)外排泵表达。
Mechanisms of antibiotics resistance includes: (1) target site modification; (2) production of inactive enzymes; (3) decrease of drugs penetrance; (4) expression of efflux pumps.
用逆转录-聚合酶链反应(RT - PCR)方法检测主动外排泵基因CDR1和CDR2的表达水平。
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure the mRNA levels of active efflux gene CDR1 and CDR2.
精氨酸载体通过泵之间的膜进入细胞，从而避开泵外排。
The arginine transporter manages to avoid ejection by slipping through the membrane of the cell in between the pumps.
精氨酸载体通过泵之间的膜进入细胞，从而避开泵外排。
The arginine transporter manages to avoid ejection by slipping through the membrane of the cell in between the pumps.
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