通过cdk2磷酸化的cdc6阻止其降解，允许前复制复合体的形成（5）。
Phosphorylation of cdc6 by cdk2 prevents its degradation, allowing pre-replication complexes to form (5).
该复合体也是前复制复合体(pre - RC)的关键组成部分(回顾1)。
This complex is also a key component of the pre-replication complex (pre-RC) (reviewed in 1).
增殖细胞核抗原(pcna)是真核生物复制复合体的核心成分，为DNA合成所必需。
Proliferating cell nuclear antigen (PCNA) is the kernel component of replication complex of eukaryotic organism, and needed for DNA synthesis.
OR c结合DNA后允许其它蛋白如cdc6和MCMs的有序结合，从而形成前复制复合体(Pre - RCs)。
ORC binding to DNA permits the ordered binding of other proteins such as cdc6 and MCMs to form pre-replication complexes (Pre-RCs).
前复制复合体（Pre-RC）在有丝分裂末期/G1早期随着CDT1和cdc6的结合而形成，允许异源六聚化的MCM2-7复合体的结合。
The pre-replication complex (Pre-RC) forms in late mitosis/early G1 phase beginning with the binding of CDT1 and cdc6 to the origin, which allows binding of the heterohexameric MCM2-7 complex.
前复制复合体（Pre-RC）在有丝分裂末期/G1早期随着CDT1和cdc6的结合而形成，允许异源六聚化的MCM2-7复合体的结合。
The prereplication complex (Pre-RC) forms in late mitosis/early G1 phase beginning with the binding of CDT1 and cdc6 to the origin, which allows binding of the heterohexameric MCM2-7 complex.
起始识别复合物（ORC）是一种高度保守的异源六聚化蛋白复合体，它与DNA复制起始位点处或其附近的DNA相关。
The origin recognition complex (ORC) is a highly conserved heterohexameric protein complex that associates with DNA at or near initiation of DNA replication sites.
MCM复合体被认为是一种复制解旋酶，而pre-RC的形成参与染色质许可。
The MCM complex is thought to be the replicative helicase, and formation of the pre-RC is referred to as chromatin licensing.
MCM复合体被认为是一种复制解旋酶，而pre-RC的形成参与染色质许可。
The MCM complex is thought to be the replicative helicase, and formation of the pre-RC is referred to as chromatin licensing.
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