综述了喜树碱及其衍生物的小分子、大分子和轭合物前药的研究进展，为新型喜树碱前药的合理药物设计提供一定参考。
The recent progress in low molecular, high molecular and couplet prodrugs of CPTs was reviewed in classified manner, provide a reference for the design of prodrugs of CPTs.
合理化药物设计利用靶分子和其结合分子的高分辩率结构。
Rational drug design (also known as structure-based drug design) uses the high-resolution (atomic) structure of the target molecule, and of molecules that bind to it.
计算机辅助药物分子设计近年来已成为新药创制的重要手段。 基于结构的合理药物分子设计则是多学科交互融合和渗透的体现。
Computer-aided molecular design (CAMD) is now an uprising subject in medicinal chemistry among which structure-based rational drug design is attracting more and more attention.
合理进行药物分子设计的前提是对药物—靶分子作用机制有深入的了解。
The rational drug design is based on the detailed knowledge of the action mechanism.
本缓释体可避免酸性（碱性）成分的过度释放给肌体带来的不良影响。使药物配方设计更趋合理。
The sustained release carrier can avoid bringing poor influences to muscles through excessive release of the acid (alkali) components, thereby enabling design of a drug formula to be more reasonable.
本缓释体可避免酸性（碱性）成分的过度释放给肌体带来的不良影响。使药物配方设计更趋合理。
The sustained release carrier can avoid bringing poor influences to muscles through excessive release of the acid (alkali) components, thereby enabling design of a drug formula to be more reasonable.
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