目的:采用环糊精包合以及眼用凝胶的方法,制备利福平滴眼液,并比较环糊精包合和眼用凝胶对利福平稳定性的提高程度。
OBJECT: To prepare rifampicin eye-drop by using cyclodextrin inclusion compound or ophthalmic gel, and investigate their ability to improve the stability of rifampicin eye-drop.
结果 :利用酸碱中和反应不但解决了利福平溶解困难和滴眼液的渗透压问题 ,还可避免以乙醇为溶剂而产生对眼睛的刺激性。
RESULTS:Neutralization reaction not only overcame the difficulty of Rifampicins dissolution in water, but also avoided the irritation to eyes caused by using ethanol as.
结果 :利用酸碱中和反应不但解决了利福平溶解困难和滴眼液的渗透压问题 ,还可避免以乙醇为溶剂而产生对眼睛的刺激性。
RESULTS:Neutralization reaction not only overcame the difficulty of Rifampicins dissolution in water, but also avoided the irritation to eyes caused by using ethanol as.
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