• 利用杜香挥发油的促渗作用,配制了保湿润肤霜。

    The moisture cream was confected using promote permeation function of volatile oil of Ledum.

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  • 目的:研究不同促渗剂对复方黄芩巴布剂透皮吸收的影响。

    OBJECTIVE: To study the effects of different penetration enhancer on the transdermal permeation of Complex Scutellaria Baicalensis cataplasm.

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  • 研究一种新型促渗剂——噻酮对皮肤组织光透明效果的影响。

    Thiazone, a kind of new enhancer, is introduced to investigate the effect of optical clearing on skin tissue.

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  • 萜类是目前公认的安全有效促渗剂,尤其是对于水溶性化合物。

    Terpenes were accepted commonly as safe and efficient transdermal enhancer, especially for that being hydrophilic.

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  • 目的观察几种促渗剂对一贴灵贴剂的抗炎镇痛疗效,确定最佳促渗剂。

    Objective: To observe the effect of several osmo promoters in Yitieling paster on anti inflammation and analgesic, and define the best one.

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  • 目的:研究丁螺环酮的经皮渗透性,筛选出丁螺环酮贴剂的促渗剂及最佳促渗浓度。

    Objective:To optimize the type and concentration of permeants for buspirone patch by characterizing the percutaneous permeability of buspirone patch in vitro.

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  • 方法采用小鼠离体皮肤作为渗透屏障,研究不同浓度氮酮对阿糖胞苷促渗作用的影响。

    Methods Rats skin in vitro was applied, studying the effect of different concentrations of azone in Cytarabine ointment on drug permeation.

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  • 结果:在贴剂处方中加入促渗剂后,药物累积透过量增加,而皮肤层中的滞留药量减少。

    Results: the cumulative penetration amounts released from the patch increased, while the part lagged in the skin decreased at the same time.

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  • 目的考察几种促渗剂对青蒿琥酯体外经皮吸收的影响,为青蒿琥酯贴剂的开发提供参考。

    Objective To investigate the effect of penetration enhancers on the percutaneous absorption of artesunate, and provide a reference for the development of artesunate transdermal delivery systems.

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  • 这样,研制适宜的辅料如:载体、促渗材料和骨架材料等成为了研制透皮给药系统的重心。

    Therefore, the key problems in the TDDS are the development of proper auxiliary materials such as carriers, enhancers and bone materials.

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  • 目的利用表面活性剂的促渗作用,提高脂溶性药物通过电致孔形成的水性通道的经皮渗透量。

    OBJECTIVE To enhance the transdermal delivery of lipophilic drugs through the local hydrophilic transport regions (LTRs) formed during electroporation by applying surfactant.

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  • 结论:0.2%卡波姆凝胶的促渗效果最好,本实验为芍药苷透皮吸收制剂处方的优化提供依据。

    Conclusion: 0.2% carbomer was the best penetration enhancer for transdermal paeoniflorin delivery in vitro. It help to provide the optimal formulation of transdermal delivery system of paeoniflorin.

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  • 用改良的扩散装置评价了盐酸尼卡地平(1)通过脱毛大鼠皮肤的渗透动力学以及促渗剂月桂氮酮(2)的作用。

    The in vitro permeation kinetics of nicardipine hydrochloride (1) through the depilatory rat skin and the effect of laurocapram (2) using a modified diffusion cell were evaluated.

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  • 目的建立简便的紫外分光光度法测定尼莫地平体外经皮渗透量,并考察不同促渗剂对尼莫地平的体外经皮渗透影响。

    OBJECTIVE To establish a simple method of UV spectrophotometry for the permeative determination of nimodipine, and to search suitable enhancers for the permeability of nimodipine.

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  • 目的建立简便的紫外分光光度法测定尼莫地平体外经皮渗透量,并考察不同促渗剂对尼莫地平的体外经皮渗透影响。

    Objective: To investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.

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  • 结果表明,2 0 %单月桂酸甘油酯、6 %肉豆蔻酸异丙酯和10 %油酸协同作用对其贴片有良好的促渗效果。

    Results showed that the penetration effect of betamethasone patches could be improved obviously with the co-effect of 20% mono-laurin, 6% isopropyl myristate and 10% oleic acid.

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  • 结果:药物经皮渗透符合零级动力学过程,不同浓度异丙醇促渗效果为:15 %异丙醇>10 %异丙醇>5 %异丙醇。

    RESULTS: The transdermal osmotic process fitted to a zero order kinetic mechanism. The osmotic enhencer effect of 2 propanol was listed below: 15%> 10%>5%.

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  • 目的研究阿昔洛韦凝胶中的不同溶剂系统对主药体外透皮速率及对氮酮促渗作用的影响,为优化阿昔洛韦凝胶处方提供实验依据。

    Objective To study the effect of different solvent systems on in vitro penetration rate of aciclovir gel enhanced by Azone for optimizing the formulation of aciclovir gel.

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  • 结果与结论:不同浓度的氮酮对复方替硝唑凝胶中3组分的渗透性均有促进作用,其中浓度为2 %的氮酮透皮促渗作用最显著。

    RESULTS&CONCLUSION:Azone at different concentrations could promote the permeability of3ingredients of compound tinidazole gel, and2%azone had the most obvious permeation-enhancing effect.

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  • 考察含药层促渗聚合物、乳糖用量、助推层聚氧乙烯用量、助推层氯化钠用量及包衣液中含水量、醋酸纤维素浓度对释放度的影响,并对处方进行优化。

    Effects of formulation of drug layer, push layer and membrane on the release behavior of controlled release tablets were investigated and the optimal formulation was obtained.

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  • 考察含药层促渗聚合物、乳糖用量、助推层聚氧乙烯用量、助推层氯化钠用量及包衣液中含水量、醋酸纤维素浓度对释放度的影响,并对处方进行优化。

    Effects of formulation of drug layer, push layer and membrane on the release behavior of controlled release tablets were investigated and the optimal formulation was obtained.

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