首次建立了一种灵敏、简便、准确的采用手性配位交换RP- HPL C与UV联用检测盐酸安妥沙星中对映体杂质的方法。
A sensitive, simple and accurate method for enantiomeric impurity determination of antofloxacin hydrochloride was developed by chiral ligand-exchange RP-HPLC with UV detection.
大位阻取代基有利于提高对映选择性，但位阻过大降低催化活性。
The large steric hindrance group avails to the enantioselectivity, but too much steric hindrance reduces the activity.
大位阻取代基有利于提高对映选择性，但位阻过大降低催化活性。
The large steric hindrance group avails to the enantioselectivity, but too much steric hindrance reduces the activity.
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