结果原代人脑胶质瘤细胞短期培养成功。
Results The primary human glioma cells were successfully cultured.
目的观察内抑制素对人脑胶质瘤细胞增殖的影响。
Objective To observe the inhibitive effect of endostatin on human glioma cells.
目的采用噬菌体展示技术制备抗人脑胶质瘤单抗。
Objective To produce monoclonal antibody specific for human brain glioma by the phage display technique.
结论人脑胶质瘤细胞具有不同的内在放射敏感性。
Conclusion The intrinsic radiosensitivity varies in different human glioma cells lines.
目的:探讨MMP-9在人脑胶质瘤中的表达及意义。
Objietive To explore the expression and significance of MMP-9 protein in human brain glioma.
目的:探讨125i治疗人脑胶质瘤的可行性及其机制。
Objective To investigate the possibility and mechanism of 125i in treatment of glioma.
结论苯丁酸钠具有明显的促进人脑胶质瘤细胞分化的作用。
Conclusion SPB has a significant differentiation-inducing effect on human glioma xenograft, and can be used in clinical trials.
目的探讨人il4基因修饰对人脑胶质瘤的抑瘤效应及可能机制。
Objective To investigate the effects of human IL 4 gene modificated glioma cell on tumor growth.
方法以人脑胶质瘤细胞株u251为材料,制作裸鼠皮下胶质瘤模型。
Methods Subcutaneous glioma model was made using established human glioma cell line U251, and nude mouse.
目的观察不同级别人脑胶质瘤中端粒酶活性表达及与增殖、凋亡的相关性。
Objective To study the correlation between the telomerase activity expression and proliferation orapoptosis in glioma at different malignant degrees.
目的探讨人脑胶质瘤组织脆性组胺三联体(FH IT)的表达及其临床意义。
To investigate the expression of apoptosis inhibitor gene FHIT in human glioma and study its clinical-pathological implication and clinical significance.
目的:研究人脑胶质瘤组织中丝裂原激活蛋白激酶(MAPK)的表达及活化情况。
Aim: to explore the expression and abnormal activation of mitogen-activated protein kinase (MAPK) in the development and progression of cerebral gliomas.
目的研究白藜芦醇对人脑胶质瘤细胞U251细胞生长抑制及诱导细胞凋亡的作用。
Objective To investigate the effects of resveratrol on inhibiting proliferation and inducing apoptosis of U251 cells.
目的:研究人脑胶质瘤组织中丝裂原激活蛋白激酶(MAPK)的表达及活化情况。
Objective To investigate the expression changes of mitogen activated protein kinase (MAPK) in Alzheimers disease (AD) rat model.
目的探讨膜型基质金属蛋白酶-1在人脑胶质瘤中的表达及其与肿瘤生物学行为和预后的关系。
Objective To investigate the expression of membrane type-1 matrix metalloproteinase(MT1-MMP) in human glioma and its relationship to clinicopathological factors and prognosis of glioma patients.
目的探讨基质金属蛋白酶MMP -2和MMP -9对人脑胶质瘤侵袭微生态系统的影响。
Objective To explore the influence of MMP 2 and MMP 9 on invasive microecosystem of human brain glioma.
目的研究三苯氧胺(TAM)对人脑胶质瘤细胞SHG - 44增殖的影响并探究其可能机制。
Objective To investigate the effects of tamoxifen (tam) on proliferation of SHG-44 glioma cells and explore its possible mechanism.
结果:该杂交瘤细胞株分泌抗人脑胶质瘤细胞单克隆抗体H12具有与脑胶质瘤细胞特异性结合的特性。
Result:The monoclonal antibody H12 against human glioma which the hybridizing cell secretions can consociate specifically with human glioma.
目的:探索人脑胶质瘤细胞原代培养的方法,提高原代培养的成功率,快速构建人脑胶质瘤细胞体外试验模型。
OBJECTIVE: to explore the method of primary human glioma cells culture, to improve the success rate of primary culture, and to establish an experimental model for studying glioma in vitro.
目的探讨微血管密度(MVD)和基质金属蛋白酶9(MMP 9)的表达与人脑胶质瘤恶性程度及预后的关系。
Objective To explore the relation between micro vascular density (MVD), expression of matrix metalloproteinase-9 (MMP-9) and malignancy in glioma.
结论用基因芯片筛选正常脑组织与人脑胶质瘤差异表达的基因,具有样品用量少,高质量,高速度,高敏感等特性。
Conclusion cDNA microarray technology can be successfully applied to identify differentially expressed genes with small amount of specimen, high quality, high speed, and high sensitivity.
目的探讨人脑胶质瘤中血管内皮细胞生长因子(VEGF)的表达与微血管数量(MVQ)和肿瘤良恶性程度的关系。
Objective to investigate the relationship between the expression of vascular endothelial growth factor (VEGF), the microvessel quantity (MVQ) and the grade in human brain gliomas.
方法建立人脑胶质瘤和转输人外周血单个核细胞于SCID小鼠体的人肿瘤人淋巴细胞的嵌合模型,并用SEC治疗之。
Methods Human lymphocytes were transplanted to human glioma-bearing SCID mice to establish the chimeric model of human tumor and lymphocytes. SEC was applied for tumor treatment.
结论:成功地克隆、表达及纯化NBEAL1蛋白,NBEAL1蛋白在人脑胶质瘤组织中的表达与其恶性程度呈负相关。
Conclusion: the NBEAL1 protein has been successfully cloned, expressed and purified. NBEAL1 protein expression in glioma tissues is negatively associated with the pathological grades of glioma.
结论局部分泌的AK(1 ~3)蛋白能抑制裸鼠皮下人脑胶质瘤血管生成和肿瘤生长,可进一步用于实体瘤的治疗研究。
Conclusion the human glioma angiogenesis and growth were inhibited by the local secretion of AK (1 3). It can be further used in the treatment of other solid tumors.
目的 检测人脑胶质瘤中肿瘤浸润淋巴细胞 (TIL)是否存在抗原受体基因的限制性取用及其类型 ,探讨其免疫学和临床意义。
Objective To investigate the type and the limitary shared of T-cell receptor(TCR) genes in tumor-infiltrating lymphocytes(TIL) of glioma specimens obtained.
目的用基因芯片技术获取人脑胶质瘤组织和人正常脑组织中差异表达的相关基因,并对部分基因在不同级别胶质瘤中的表达进行初步研究。
Objective To identify the genes differentially expressed in development of human glioma, and to study the expression of some genes in different grade gliomas.
联合检测三者的表达水平对判断肿瘤的恶性程度有一定的参考意义,同时,这三个因子可作为判断与预测人脑胶质瘤患者预后的重要指标。
The assay of the three factors has referential significance to the estimation of tumor malignant degree, and the three factors can be used as the important markers of gliomas prognosis.
目的探讨热休克蛋白90 (HSP90)在人脑恶性胶质瘤的表达及其在肿瘤增殖、分化中的作用。
Objective To probe the expression and role of the heat-shock protein 90 (HSP90) in the proliferation and differentiation of human brain gliomas.
目的探讨热休克蛋白90 (HSP90)在人脑恶性胶质瘤的表达及其在肿瘤增殖、分化中的作用。
Objective To probe the expression and role of the heat-shock protein 90 (HSP90) in the proliferation and differentiation of human brain gliomas.
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