现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤。
Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication.
这些蛋白被认为参与中心体微管装配且其染色体区域定位在一些癌症中是被破坏的（2中已论述）。
These proteins are thought to be involved in centrosomal microtubule assembly and have been mapped to chromosomal regions that are disrupted in some cancers (reviewed in 2).
Polo样蛋白激酶也可以磷酸化粘连蛋白亚基scc1，引起染色体臂的粘连蛋白移位，促进粘连蛋白的中心体适当定位(7)。
Polo-like kinases also phosphorylate the cohesin subunit SCC1, causing cohesin displacement from chromosome arms that allow for proper cohesin localization to centromeres (7).
Polo样蛋白激酶也可以磷酸化粘连蛋白亚基scc1，引起染色体臂的粘连蛋白移位，促进粘连蛋白的中心体适当定位(7)。
Polo-like kinases also phosphorylate the cohesin subunit SCC1, causing cohesin displacement from chromosome arms that allow for proper cohesin localization to centromeres (7).
应用推荐